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Tissue Specific Stem Cells

Tissue specific stem cells are a multi-potent cell population. They have the unique potential to self-renew and differentiate into predetermined cell types. Because of these characteristics, these cells hold great promise for cell  replacement therapy and drug screening.

Before the full potential of these stem cells can be realized......

Cardiac Progenitors              Pre-Cardiomyocytes

Reliable and efficient conditions for differentiation of adult human stem cells into functional cells in vitro need to be developed.  In vitro conditions for differentiation partly rely on an appropriate ECMP substrate for attachment and cell signaling.

MicroStem founders have utilized this ECMP array technology to understand the effects of microenvironments and their influence on liver stellate cell fate and funtion.  Read more here.

For further information on Microstem products please click here

Cardiomyocytes and Cardiac Progenitors

Fig 2. Immunocytochemical analysis of cardiac lineage markers in DV Biologics cardiac cells and cardiomyocytes. (A) Cardiac cells were stained with actin (green) and troponin T (red) antibodies. (B) Cardiomyocytes express myosin heavy chain (green) and troponin T (red). Note the multinucleated pattern.

Cardiomyocytes are highly specialized heart muscle cells. The main function of these cells is to propel blood throughout the body by self-excitatory and involuntary contraction. They comprise 20% of the total number of cells in the heart, and due to their unique architecture, more than 90% of its mass (1). The remaining cells are endothelial cells and fibroblasts. The heart was considered a terminally differentiated organ till very recently, when the existence of human cardiomyocyte progenitor cells was described, thus challenging a long-standing dogma (2).Heart disease is the No.1 cause of death in USA. This justifies the need for an in vitro system which enables the studies of human cardiac muscle cell differentiation, growth, development, and regenerative medicine.   In addition, an in vitro system would facilitate cardiac drug toxicology studies.

Further Information on Cardiomyocytes and Cardiac Progenitors

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Handelsregister: HRB 197203
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